All entries by this author

Jun 25th, 2021 | By

Discovery Ridge at Mizzou: A unique NextGen Precision Health resource and one of a kind in the USA Not many at MU are aware of the truly unique research facilities we have here on our campus that make us a global center for animal research. Animal model research uses similarities between humans and other species to understand biological processes and develop disease therapies that would not be otherwise possible. I visited Discovery Ridge in December to get a tour of two unique NIH-funded research centers at Mizzou that enable our investigators and other scientists around the country and world to take on leading edge scientific biologic discovery: the Mutant Mouse Resource and Research Center (MMRRC) and the Rat Resource and Research Center (RRRC). In my field of specialization, neuromuscular disease, astonishing treatments have been developed in the last 20 years that have dramatically changed the outcomes of patients who inherit damaged and mutated genes that can result in death. Two such examples are spinal muscular atrophy (SMA) and Duchenne muscular dystrophy. Scientists have been able to produce animal models of both of these diseases to show that various types of gene therapy can slow down, and in some cases essentially stop, disease progression. Pictured, from left to right, are Dr. Craig Franklin, MMRRC co-director; myself; Dr. Elizabeth Bryda, RRRC director; Dr. Bill Fay, senior associate dean for research at the School of Medicine; Dr. Chris Lorson, associate dean for research and graduate studies in the College of Veterinary Medicine; and Dr. Jim Amos-Landgraf, MMRRC co-director.     MU is home to four NIH-funded animal model resource centers of global importance, making it an essential part of the NextGen Precision Health pipeline that will efficiently transform research findings into clinical therapy. The centers encompass the major animal models used in research: the National Swine Resource and Research Center (NSRRC) and the Swine Somatic Cell Genome Editing Center, led by Randall Prather, PhD, and Kevin Wells, PhD the RRRC, led by Elizabeth Bryda, PhD the MMRRC, led by Craig Franklin, DVM, PhD, and Jim Amos-Landgraf, PhD Researchers around the world are dependent on these facilities to serve as primary repositories and distribution systems for rodent and porcine research models that are critical to biomedical research. Three related programs housed at Discovery Ridge include: the MU Comparative Medicine Program, a program that trains the next generation of scientists, under the direction of Dr. Franklin, Erin O’Connor, DVM, MS, and Dr. Bryda the MU Metagenomics Center (MUMC), where DNA samples from animal models can be stored and analyzed, under the direction of Aaron Ericsson, DVM, PhD the MU Animal Modeling Core (AMC), where genetically engineered animals can be created, under the direction of Dr. Bryda MU is a national leader in comparative medicine, collaborating to share discoveries, innovations, and treatments for animals and humans. Under the leadership of Dean Carolyn Henry, DVM, MS, ACVIM (Oncology), the MU College of Veterinary Medicine is an essential partner in this research. We also have an industry partner in the facility, IDEXX BioAnalytics, a diagnostic lab which was developed at MU and provides services to laboratories around the country to ensure their animals are free of microbial contaminants. This expertise empowers NextGen Precision Health by providing animal models for human disease, technical expertise to investigators and services for testing therapeutics in pre-clinical animal

[continue reading…]



Welcome to the CMP

Dec 2nd, 2020 | By

Welcome to MU’s Comparative Medicine Program. With flexible training experiences, state-of the-art facilities and a tradition of excellence in the field of comparative medicine, it’s one of the top programs in the nation. Program Advantages The MU CMP couples a residency program with a research program that leads to either an MS or PhD degree. The first year of the program consists of laboratory animal medicine residency activities. In years two and three, the trainee is involved primarily in research activities (at least 40 hours/week) combined with 10-15 hours/week of laboratory animal medicine activities. The latter activities complement training gained in the first year and are part of an individual development plan generated in consultation with program faculty to facilitate pursuit of specific career goals. MS students complete their residency and degree program after three years, while PhD students complete their residency after three years and their degree program after approximately five years.CMP trainees may also elect to pursue a more clinically oriented program consisting of 1.5 years of residency activities in laboratory animal medicine followed by 1.5 years of research coupled with additional laboratory animal medicine activities at an approximately 50:50 split. Students pursuing this program generally pursue MS degrees but may switch to PhD degree programs. A maximum of one trainee/year can pursue this option. Training is designed to prepare individuals for a variety of careers including comparative medicine research, clinical and administrative laboratory animal medicine and comparative and diagnostic laboratory animal pathology. Students may pursue either a MS or PhD. Research opportunities are available in several areas including infectious disease, pathology, molecular biology, mouse biology and cardiovascular physiology. Resources available include the University of Missouri Office of Animal Resources (OAR), IDEXX BioResearch, as well as the Mutant Mouse, Rat and Swine Resource and Research Centers.



test

Dec 2nd, 2020 | By

test



Test

Nov 30th, 2020 | By

Test